Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Dosage
<10 mg>
The recommended dose of EZEMANTIS for adults and elderly patients is 20 mg once a day.
In order to reduce the risk of side effects this dose is achieved gradually by the following daily treatment scheme:
| week 1 | half a 10 mg tablet |
| week 2 | one 10 mg tablet |
| week 3 | one and a half 10 mg tablet |
| week 4 and beyond | two 10 mg tablets once a day |
The recommended dose can also be achieved by using a treatment initiation pack.
The usual starting dose is half a tablet once a day (1x 5 mg) for the first week. This is increased to one tablet once a day (1x 10 mg) in the second week and to 1 and a half tablet once a day in the third week. From the fourth week on, the usual dose is 2 tablets once a day (1x 20 mg).
<20 mg>
The recommended dose of EZEMANTIS for adults and elderly patients is 20 mg once a day.
In order to reduce the risk of side effects this dose is achieved gradually by the following daily treatment scheme. For up-titration other tablet strengths are available.
At the beginning of treatment you will start by using EZEMANTIS 5 mg film-coated tablets once a day. This dose will be increased weekly by 5 mg until the recommended (maintenance) dose is reached. The recommended
| issue date: 05-09-13 | version: M1.3.1_03.MMN.hcl.tab.101.03.nl.2699.01 approved: CHo |
Common Technical Document
Memantine HCl
Film-coated tablets
| Module 1 - Section 3.1 SPC, Labelling | |
| and Package Leaflet | page 5/9 |
maintenance dose is 20 mg once a day, which is reached at the beginning of the 4th week.
Dosage in patients with impaired kidney function
If you have impaired kidney function, your doctor will decide upon a dose that suits your condition. In this case, monitoring of your kidney function should be performed by your doctor at specified intervals.
<10 mg>
Breaking the tablet
Place the tablet with the round side on a hard surface, the score line should face upwards. Press with the forefinger and thumb of the same hand on either side of the score line and push down until the tablet breaks as shown in the illustration.
<20 mg>
Breaking the tablet
Place the tablet with the round side on a hard surface, the score line should face upwards. Press with the forefinger and thumb of the same hand on either side of the score line and push down until the tablet breaks as shown in the illustration.
Administration
EZEMANTIS should be administered orally once a day. To benefit from your medicine you should take it regularly every day at the same time of the day. The tablets should be swallowed with some water. The tablets can be
| issue date: 05-09-13 | version: M1.3.1_03.MMN.hcl.tab.101.03.nl.2699.01 approved: CHo |
Common Technical Document
Memantine HCl
Film-coated tablets
| Module 1 - Section 3.1 SPC, Labelling | |
| and Package Leaflet | page 6/9 |
| taken with or without food. | |
| Duration of treatment | |
Continue to take EZEMANTIS as long as instructed by your doctor. He will assess your treatment on a regular basis.
If you take more EZEMANTIS than you should
In general, taking too much EZEMANTIS should not result in any harm to you. You may experience increased symptoms as described in section 4, Possible side effects.
If you take a large overdose of EZEMANTIS, contact your doctor or get medical advice, as you may need medical attention.
If you forget to take EZEMANTIS
If you have forgotten to take your dose of EZEMANTIS, wait and take your next dose at the usual time.
Do not take a double dose to make up for the forgotten dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
