Trospium

Trospium or its chloride salt is an antispasmodic drug used to treat the symptoms of hyperactive bladder. It belongs to the group of parasympatholytics. The active ingredient is commercially available in coated tablet form.

Pharmacodynamics

Trospium inhibits the neurotransmitter acetylcholine, which controls the state of tension in many organs. The antispasmodic properties of the active ingredient cause relaxation of the urinary bladder wall muscles and tension of the bladder sphincter. This improves symptoms such as urinary incontinence, urinary urgency and frequent urination.

Pharmacokinetics

Due to its hydrophobic state, the drug hardly passes the blood-brain barrier and therefore shows practically no adverse effects on the central nervous system.
Die Aufnahme in den Organismus beträgt nur 9,6% und zirkuliert zu 50-85% proteingebunden. Trospium hat eine Halbwertzeit von 20 Stunden. Die Ausscheidung erfolgt hauptsächlich über den Stuhl.

Contraindications

The agent should not be used in the following conditions:

• Urinary retention
• Untreated glaucoma
• Benign enlargement of the prostate
• Myasthenia gravis (neuromuscular autoimmune disease)
• Cardiac arrhythmias
• Pyloric stenosis (narrowing of the gastric outlet)
• Chronic inflammatory bowel disease and megacolon
• Renal insufficiency requiring dialysis

Side effects

The most common side effects include:

• Dry mouth
• Skin redness
• decreased perspiration
• Blurred vision
• bloating, constipation
• Abdominal pain
• Nausea

Toxicological data

LD50 (mouse, oral): 812 mg/kg
LD50 (Maus, intravenös): 11,2 mg/kg