Basics

Pantoprazole is a drug from the group of proton pump inhibitors. Pantoprazole reduces the overproduction of stomach acid and is therefore used to treat reflux oesophagitis and stomach and duodenal ulcers. It is administered in the form of tablets and is no longer available by prescription.

Pharmacology

Pharmacodynamics

Pantoprazole is an irreversible inhibitor at proton pumps in the gastric mucosa. It irreversibly binds to these pumps and prevents protons, which are essential for the formation of gastric acid, from entering the stomach.

Pharmacokinetics

Panotprazole is absorbed in the intestine and reaches its highest plasma concentration at 2-3 hours after ingestion. Oral bioavailability is approximately 77% and plasma protein binding is approximately 98%. The active substance is degraded by the CYP-450 system in the liver and the majority is subsequently excreted in the urine.

Toxicity

Side effects

Pantoprazole is considered to be a very safe drug with few side effects. Rare side effects include dizziness, headache, and diarrhea.

Author

Markus Falkenstätter, BSc

Pharmacy student

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Reviewer

Mag. pharm. Stefanie Brandauer

Pharmacist

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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All information used for our content comes from verified sources (recognised institutions, specialists, studies by renowned universities). We place great value on the qualification of the authors and the scientific background of the information, so that our research is based on scientific evidence.

Pantoprazole